Dear all,
*Professor Bratislav Misic *(Montreal Neurological Institute/McConnell
Brain Imaging Centre) will be speaking in our Cognitive Area Seminar
this *Friday,
November 4th, 3:30 - 5 PM *(Room S3/4, Stewart Biology Building, 1205
Docteur Penfield Avenue).
*His talk is titled, **"* *Spreading dynamics on large-scale brain
networks."*
For a full abstract, see below the dashed line.
Please join us at this event!
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*Spreading dynamics on large-scale brain networks*
Professor Bratislav Misic, Montreal Neurological Institute, McConnell Brain
Imaging Centre
The human brain is a complex network of anatomically connected and
functionally interacting neuronal populations. Collective communication
among these distributed elements is thought to support patterned neural
activity, as well as flexible cognitive operations and complex behavior.
Recent innovations in noninvasive neuroimaging have resulted in
increasingly detailed maps of human brain connectivity patterns, creating a
need for theoretical principles that explain how these networks shape
neural communication. Here we systematically investigate how neural
signaling is constrained by anatomical connectivity in meso- and
macro-scale neural circuits. Using a simple model of cascade spreading, we
investigate a series of scenarios where focal perturbations result in
global signaling cascades that interact either cooperatively or
competitively. We find that topological features, such as community
structure and core-periphery organization, shape spreading patterns.
Moreover, anatomical embedding potentiates sensory-motor integration and
the convergence of multiple cascades towards polysensory associative areas.
Altogether, these results show that the organization of brain networks
shapes the functional properties of brain areas and facilitates integrative
function.