Dear all,
On Friday, November 16, Dr. Natasha Rajah from McGill's Psychiatry/Psychology and Director of the Douglas Brain Imaging Center will be speaking about age-related differences in episodic memory-related brain function (title & abstract below). As usual, the talk will span from 12-1 PM in room 735 of 2001 McGill College Avenue. Everyone is welcome.
For a full schedule of talks this term, please visit https://www.mcgill.ca/psychology/events-colloquia-0/brownbag-series.
To be added to the cognitive list serve and get day-of updates & information about additional talks, please visit http://mx0.psych.mcgill.ca/mailman/listinfo/coggroup.
— Age-related differences in episodic memory-related brain function Dr. Natasha Rajah Associate Professor, Department of Psychiatry Associate Member, Department of Psychology Director, Douglas Brain Imaging Centre McGill University
Age differences in brain activity have been reported during both encoding and retrieval of past events. Yet, it remains unclear whether these differences are due to age, performance, or age*performance effects. In the current presentation, I will discuss our results from an event-related fMRI study of spatial and temporal context encoding and retrieval in the adult lifespan in which we examined age and performance effects. We conducted a multivariate behavior partial least squares (B-PLS) analysis of fMRI data to differentiate age (as a continuous variable), performance (accuracy) and age*performance effects on brain activity across the adult lifespan. This analysis identified three significant effects: 1) activity in fusiform, middle occipital temporal and inferior parietal cortices increased with age and decreased with performance; 2) Dorsolateral prefrontal cortex (DLPFC) and limbic activity increased with age at encoding, and increased with performance at retrieval; and 3) Right ventrolateral prefrontal and bilateral hippocampus (HC) increased with age during retrieval and was differentially related to performance during encoding versus retrieval. We then conducted a seed voxel PLS analysis to test the hypothesis that age-related increases in DLPFC and posterior HC activity may be related to altered patterns of functional connectivity between these two brain areas, and with ventral visual and fronto-parietal areas. Our findings show that advanced age was related to increased positive connectivity amongst DLPFC, posterior HC, ventral visual and parietal regions. In contrast younger adults exhibited positive connectivity between DLPFC, ventral visual and parietal regions, and negative connectivity between these regions and posterior HC. We conclude that age-related increases in positive DLPFC-HC connectivity may reflect unconstrained encoding and retrieval, which negatively impact memory performance in older adults.
Kind reminder that Dr.Natasha Rajah will speak at today’s CRAM session (12-1 PM in room 735 of 2001 McGill College). Please see below for additional information.
___________________________________ Mehrgol Tiv Ph.D. Student, Psychology, McGill University Language and Multilingualism Lab *mehrgoltiv.comhttp://mehrgoltiv.com/
On Nov 12, 2018, at 3:13 PM, Mehrgol Tiv <mehrgol.tiv@mail.mcgill.camailto:mehrgol.tiv@mail.mcgill.ca> wrote:
Dear all,
On Friday, November 16, Dr. Natasha Rajah from McGill's Psychiatry/Psychology and Director of the Douglas Brain Imaging Center will be speaking about age-related differences in episodic memory-related brain function (title & abstract below). As usual, the talk will span from 12-1 PM in room 735 of 2001 McGill College Avenue. Everyone is welcome.
For a full schedule of talks this term, please visit https://www.mcgill.ca/psychology/events-colloquia-0/brownbag-series.
To be added to the cognitive list serve and get day-of updates & information about additional talks, please visit http://mx0.psych.mcgill.ca/mailman/listinfo/coggroup.
— Age-related differences in episodic memory-related brain function Dr. Natasha Rajah Associate Professor, Department of Psychiatry Associate Member, Department of Psychology Director, Douglas Brain Imaging Centre McGill University
Age differences in brain activity have been reported during both encoding and retrieval of past events. Yet, it remains unclear whether these differences are due to age, performance, or age*performance effects. In the current presentation, I will discuss our results from an event-related fMRI study of spatial and temporal context encoding and retrieval in the adult lifespan in which we examined age and performance effects. We conducted a multivariate behavior partial least squares (B-PLS) analysis of fMRI data to differentiate age (as a continuous variable), performance (accuracy) and age*performance effects on brain activity across the adult lifespan. This analysis identified three significant effects: 1) activity in fusiform, middle occipital temporal and inferior parietal cortices increased with age and decreased with performance; 2) Dorsolateral prefrontal cortex (DLPFC) and limbic activity increased with age at encoding, and increased with performance at retrieval; and 3) Right ventrolateral prefrontal and bilateral hippocampus (HC) increased with age during retrieval and was differentially related to performance during encoding versus retrieval. We then conducted a seed voxel PLS analysis to test the hypothesis that age-related increases in DLPFC and posterior HC activity may be related to altered patterns of functional connectivity between these two brain areas, and with ventral visual and fronto-parietal areas. Our findings show that advanced age was related to increased positive connectivity amongst DLPFC, posterior HC, ventral visual and parietal regions. In contrast younger adults exhibited positive connectivity between DLPFC, ventral visual and parietal regions, and negative connectivity between these regions and posterior HC. We conclude that age-related increases in positive DLPFC-HC connectivity may reflect unconstrained encoding and retrieval, which negatively impact memory performance in older adults.