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Events

Cognition & Circuits Lecture Series Inhibition and plasticity in the auditory cortex - the role of sensory experience, learning, and aging

Mike Cisneros-Franco, MD PhD candidate | de Villiers-Sidani Lab Montreal Neurological Institute | McGill University

Wednesday, January 30th , 2019 4 pm ** Please note special room: Jeanne Timmins Amphitheatre** *PS. Coffee & snacks will be served*

Abstract: The brain is particularly plastic during critical periods (CP) of early development before many key neural circuits are formed. This property is what makes early experience crucial for the development of language and musical abilities and why mastering these skills in adulthood poses a far greater challenge. Upon CP closure, further circuit rewiring is regulated by a range of functional and structural elements including the inhibitory activity of GABAergic interneurons such as parvalbumin-positive (PV+) cells, extracellular matrix components including perineuronal nets (PNNs), and myelin-associated proteins. How are these regulatory elements of plasticity modified by changes in the environment, aging, and training? Is it possible to manipulate inhibition to enhance the acquisition and persistence of learning? Can too much plasticity be detrimental? In the de Villers-Sidani lab, we tackle these questions using a combination of in-vivo electrophysiology, operant conditioning, pharmacology and immunohistochemistry in the rat primary auditory cortex.

Next Seminars: https://www.mcgill.ca/neuro/events/cognition-and-circuits-seminar-series

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